Automated systematic review · meta-analysis · manuscript

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Q:

Arakis searches four databases, dual-screens every record, retrieves and extracts the full texts, assesses risk of bias, pools with REML + Hartung-Knapp, grades certainty, and drafts the manuscript. You adjudicate only the calls it pauses on.

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PRISMA-trAIce · ROBINS-I · GRADE

Blinded rubric · final round

Arakis vs a published Cochrane review · 8 dimensions × 5 points

ArakisHuman review
  • Question & eligibilityArakis 4vshuman review 3
  • SearchArakis 2vshuman review 1
  • Selection & flowArakis 3vshuman review 2
  • Risk of biasArakis 4vshuman review 1
  • SynthesisArakis 4vshuman review 3
  • Certainty of evidenceArakis 4vshuman review 1
  • Interpretation disciplinelostArakis 3vshuman review 4
  • ReproducibilityArakis 3vshuman review 1
Total27 / 40vs16 / 40

One question, one reviewer. Scores are not comparable across rounds.

How we measured
Built on evidence standards
PRISMA 2020GRADE certaintyCochrane-style methodsPRISMA-trAIce transparencyREML + HKSJ meta-analysisRisk-of-bias assessmentHuman-in-the-loop reviewFull audit trailPRISMA 2020GRADE certaintyCochrane-style methodsPRISMA-trAIce transparencyREML + HKSJ meta-analysisRisk-of-bias assessmentHuman-in-the-loop reviewFull audit trail

The problem

Why a systematic review takes a year — and still ships errors.

67 weeks

Mean time from registration to publication across 195 PROSPERO-registered medical-intervention reviews — and the authors note this understates the real elapsed time.1

What Arakis does

Runs the pipeline to completion and pages you only for adjudication.

~$141,000

Estimated cost of a single systematic review at academic institutions, based on 1.72 scientist-years of labour.2

What Arakis does

$9 per completed review; you keep the judgment, not the labour.

3,585 records

Median title/abstract screening set across 259 systematic reviews — the largest single workload in a review.3

What Arakis does

Two independent AI passes on every record; disagreement and malformed output both become MAYBE for you to decide.

67%

Of meta-analyses contain at least one trial with a data-extraction error.4

What Arakis does

Every extracted number traces to a span in the source; extraction review is a stage, not an afterthought.

42%

Median PRISMA adherence in systematic review abstracts; 0% of PROSPERO-uploaded protocols adhered completely to PRISMA-P.5

What Arakis does

PRISMA 2020 flow and a PRISMA-trAIce transparency report are generated from the run, not written from memory.

23%

Of systematic reviews are signalled as out of date within two years of publication.6

What Arakis does

Every stage checkpoints; rerun the search and the downstream stages rebuild with a before/after diff.

How it works · 15 stages, 4 phases

Every stage checkpoints.
Every decision is yours.

Phase 010102

Find

Boolean strategies generated from your question and executed against PubMed, ClinicalTrials.gov, OpenAlex and Semantic Scholar. Embase, Scopus and Web of Science with your institution's API key. CENTRAL and CINAHL by import.

  • 01Search
  • 02Search completeness
Phase 020308

Filter & extract

Two independent AI passes per record. MAYBEs and conflicts stop the run until you rule. Full texts retrieved through your own library access; abstract-only records are labelled as such, never counted as success.

  • 03Title & abstract screen
  • 04Full-text retrieval
  • 05Full-text screen
  • 06Extraction
  • 07Extraction review
  • 08Risk of bias
Phase 030911

Synthesize

Random-effects pooling (REML, Hartung-Knapp), prediction intervals, Egger, leave-one-out, subgroups, GRADE per domain. Fewer than two compatible studies and Arakis says so instead of inventing a pool.

  • 09Meta-analysis & GRADE
  • 10PRISMA 2020 flow
  • 11Tables & figures
Phase 041215

Write

A full draft with figures and citations, every numeric claim reconciled against checkpoint data or flagged as unverified.

  • 12Introduction
  • 13Methods
  • 14Results
  • 15Discussion

Evidence

We scored it blind against a published Cochrane review.

Competitors quote hours saved and testimonials. We put an Arakis manuscript and a published human review in front of a reviewer who did not know which was which, on an 8-dimension methodological rubric. Here is the whole result, including the dimension we lost.

Blinded rubric · final round8 dimensions, 5 points each, scored by a reviewer blind to authorship.
DimensionArakisPublished reviewResult
Question & eligibility43won
Search21won
Selection & flow32won
Risk of bias41won
Synthesis43won
Certainty of evidence41won
Interpretation discipline34lost
Reproducibility31won
Total27 / 4016 / 407 of 8 dimensions

Comparator

Cochrane 2024 review of zinc for the common cold (Nault et al.)

doi:10.1002/14651858.CD014914.pub2

Round history

ArakisPublished review

Within-round gap only — totals are not comparable across rounds

What this does not prove

  • One clinical question, one published comparator, one fresh reviewer per round.
  • Absolute scores are not comparable across rounds: the unchanged human manuscript scored 25/40 in one round and 17/40 in the next. Only the within-round gap carries information.
  • The search corpus was human-supplied. A cold-start run and a second question are not yet proven.
  • Arakis lost Interpretation discipline (3 vs 4). Fixes have shipped but have not been re-measured blind.

Full protocol, rubric and per-round scores are in the repository's benchmarking record. Ask for it in the form below.

Guardrails

Built to refuse to fabricate.

01 / 06

Dual screening, always.

Never downgraded to a single pass for cost.

02 / 06

Malformed output is a MAYBE, not an exclusion.

Zero silent exclusions.

03 / 06

MAYBEs block completion.

Screening cannot finalise with an unreviewed MAYBE.

04 / 06

Fewer than two compatible studies → no pool.

meta_analysis_feasible=false with a machine-readable reason, never a placeholder estimate.

05 / 06

Certainty language follows the GRADE profile.

No robustness claim without a sensitivity analysis, no safety claim without adverse-event synthesis.

06 / 06

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Compare

Where the others stop.

Vendor pages, September 2026. Tell us if we got one wrong.

Feature and price comparison of Arakis against Covidence, Rayyan, Nested Knowledge, Elicit and RevMan, from vendor pages as of September 2026.
CapabilityArakisCovidenceRayyanNested KnowledgeElicitRevMan
Executes the database searchYesNo(import)No(import)partialYesNo
Dual AI screening with human adjudicationYespartial(human dual)partialYespartialNo
Full-text retrievalYesNoNoNopartialNo
Extraction with source-span traceabilityYesmanualmanualmanualYesNo
Risk of bias (RoB 2, ROBINS-I, QUADAS-2 …)YesmanualmanualmanualNoNo
Pooled meta-analysis (random effects, HKSJ)YesNo(export)NoYesNoYes
GRADE certainty per domainYesNoNoNoNoYes
Manuscript draft with reconciled numbersYesNoNoYespartial(report)partial
Published blinded head-to-head vs a human reviewYes(one)NoNoNoNo(self-run eval)No
Price$9 / completed review$339 / yrfree–$40 / mo$19.95–$695 / user / mo$12–$89 / mofree–£560+

Sources (vendor pages, September 2026): Covidence · Rayyan · Nested Knowledge · Elicit · RevMan. Tell us if we got one wrong.

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Pricing

Pay per review. Not per month.

Save a card to start; each completed review is $9, charged only after delivery, with promotional credit applied first.

Starter credit

$100

Credit when you add a card

  • Full 15-stage pipeline access
  • PRISMA 2020 flow diagram
  • Human-in-the-loop screening review
  • Export to Markdown/DOCX
POPULAR

Per Review

$9/review

Charged only after completion

  • Starter credit is applied first
  • Meta-analysis with GRADE certainty
  • Risk-of-bias assessment
  • Forest, funnel & PRISMA figures
  • PRISMA-trAIce transparency report
  • 30-day money-back guarantee

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